England's injured openside quartet
England will negotiate their entire autumn series without four players who were under consideration at openside until injury struck.
Here, Press Association Sport examines the quartet.
James Haskell, Wasps, 31-years-old, 70 caps
The first to be ruled out, Haskell limped off towards the end of the second Test of the 3-0 series whitewash of Australia in June and has not played since having undergone foot surgery. Expected to return in December.
Jack Clifford, Harlequins, 23-years-old, 8 caps.
Haskell's injury was the perfect opportunity for Clifford to win a starting place in England's back row until ankle damage incurred on Aviva Premiership duty ruled him out for 10 weeks and he is due back mid-December.
Sam Jones, Wasps, 24-years-old, 0 caps
A bulldozing start to the season from the Wasps flanker was brought to an end by a judo session during England's training camp in Brighton. A broken right leg and ankle damage has left Jones sidelined for five months.
Mike Williams, Leicester, 24-years-old, 0 caps
To complete an astonishing run of injuries in one position, Williams was told that a broken arm sustained during a tackle drill in a pre-match warm-up would sideline him for eight to 12 weeks.