Exeter Chiefs claimed a historic Amlin Challenge Cup victory over European giants Perpignan to secure their first appearance in a European quarter-final.
The Chiefs looked destined for a heavy loss as the French club surged into a 14-0 lead within 10 minutes of kick-off but turned the game around thanks to the boot of Ignacio Mieres and a Hayden Thomas try.
Brett Sturgess and James Phillips then grabbed second-half touchdowns to seal the 31-14 win and qualification to the knockout stages. But Exeter will have to wait until Wasps' clash with Bordeaux-Begles on Sunday to learn if they have done enough for a home quarter-final.
Newport Gwent Dragons ended their campaign with a convincing 45-16 win over Cavalieri Prato.
Rhys Buckley, Adam Hughes, Aled Brew, Andy Tuilagi, Jason Tovey, Martyn Thomas and Lewis Roblin all scored.
Redford Pennycook scored for Newcastle Falcons but it was not enough to prevent a 21-13 loss in Lyon.
The openside claimed his first try of the season, following an impressive break from Mark Wilson, to cancel out Mosese Ratuvou's early score. Jimmy Gopperth slotted the conversion and then kicked the Falcons 13-7 ahead with a brace of penalties either side of half-time.
However, they failed to press home their advantage at Matmut Stadium, where Lyon responded with a penalty try converted by Romain Loursac before replacement Laurent Tranier stepped off the bench to cross for the home team's third try.
Jonny Wilkinson guided Toulon to a home draw in the quarter-finals with a comfortable 50-6 victory in Italian over minnows Petrarca, while Bucharest Wolves won 26-13 at Banca Monte Crociati in Pool One.
Elsewhere, Worcester suffered their heaviest defeat in Europe for seven years, a 33-10 reverse at Stade Francais, to end any hope of progressing.