England fly-half Owen Farrell scored all 18 points for the visitors as Saracens consigned Harlequins to an 18-16 loss, their first defeat in five Aviva Premiership matches this season.
Farrell scored six penalties, including the winning one six minutes from time, in a hard-fought encounter at the Twickenham Stoop. Harlequins replied with an opportunist try from scrum-half Danny Care and 11 points from the boot of fly-half Nick Evans.
But the usually dependable former All Black missed three kickable second-half penalties, any one of which would have been enough to preserve Quins' 100 per cent record this season.
Evans kicked Harlequins into a second-minute lead but six minutes later he saw a second attempt rebound off the post after Sarries flanker Will Fraser pulled down a rolling maul. Saracens drew level in the 12th minute with Farrell's simple opening penalty after Harlequins strayed offside.
Two minutes later Evans restored his side's lead with his second successful kick. Farrell equalised again in the 21st minute after former England number eight Nick Easter was penalised for not rolling away from a ruck.
The first try-scoring opportunity was wasted by Quins. Evans found Easter but, with full-back Mike Brown outside him, the back-row man's final pass went straight into the arms of Saracens' England wing Chris Ashton.
But 14-man Quins put the misfortunes behind them when Care, looking far more lively than England scrum-half rival and opposite number Richard Wigglesworth, scored a real sniper's try. Exploiting a rare gap in the Premiership's meanest defence, he dashed clear to touch down near the posts, leaving Evans a simple conversion.
Farrell reduced Quins' lead to a single point with a 45-metre penalty four minutes into the second half. Then hooker Brits produced a touch of magic worthy of a half-back when he found space and directed an inch-perfect kick into the corner for the chasing Ashton but he was once again thwarted by Brown's first-class covering.
Evans missed a 52nd-minute penalty kick for Harlequins and, three minutes later, Farrell kicked the visitors ahead after Quins were penalised at the breakdown. Evans was off-target again in the 62nd minute after Sarries' replacement prop Mako Vunipola was penalised for entering a ruck from the side.
But Evans made no mistake from in front of the posts in the 66th minute after Saracens' replacement lock George Kruis was yellow-carded for hands in the ruck. Evans then missed another penalty shot before Farrell kicked the winner in the 74th minute.