Habana blow for Springboks
South Africa wing Bryan Habana will play no further part on the tour of Ireland and Great Britain after breaking a bone in his hand during training.
Habana suffered the injury during a defensive drill on Tuesday when he fell awkwardly.
His place against Scotland has been taken by Lwazi Mvovo, who was originally named on the bench for the Murrayfield clash, with Adi Jacobs among the replacements.
Coach Peter de Villiers had earlier announced three changes to the starting XV, with one positional switch.
Full-back Zane Kirchner, scrum-half Francois Hougaard and number eight Ryan Kankowski come into the side, while Gio Aplon switches to the wing after playing at full-back in last Saturday's 29-25 win over Wales in Cardiff.
Scrum-half Ruan Pienaar drops to the bench, while number eight Pierre Spies drops out of the 22 altogether.
Two changes to the 22 were enforced, with winger Bjorn Basson and replacement hooker Chiliboy Ralepelle sent home after failing random tests following the 23-21 win over Ireland on November 6.
Ralepelle and Basson, who was due to fly home anyway as a result of an ankle injury picked up in the win over Wales, tested positive for stimulant methylhexaneamine, commonly used as a nasal decongestant.
South Africa team: Z Kirchner; G Aplon, F Steyn, J de Villiers, L Mvovo; M Steyn, F Hougaard; T Mtawarira, B du Plessis, J du Plessis, B Botha, V Matfield (capt), D Stegmann, J Smith, R Kankowski.
Replacements: A Strauss, CJ van der Linde, F van der Merwe, W Alberts, R Pienaar, P Lambie, A Jacobs.