James Hook will start at full-back for Wales in Friday night's RBS 6 Nations opener against England at the Millennium Stadium.
And that means no place for his fellow British and Irish Lion Lee Byrne, who features among the replacements.
Wales coach Warren Gatland has paired Jamie Roberts and Jonathan Davies together in midfield, with Scarlets wing Morgan Stoddart waearing the number 14 shirt that was destined for Leigh Halfpenny until he suffered an ankle injury during training two days ago.
As expected, Ospreys props Paul James and Craig Mitchell fill the vacancies created by injured Lions Gethin Jenkins and Adam Jones, while Wasps' Andy Powell packs down at number eight.
Former Wales captain Ryan Jones and scrum-half Dwayne Peel join Byrne on the bench, where 62-times capped Jonathan Thomas provides back-row cover.
There are seven changes from Wales' autumn Test series finale against New Zealand in November, plus a positional switch as Hook moves from centre to full-back.
Roberts, meanwhile, returns after missing the entire autumn series through injury, and Wales' record try-scorer Shane Williams has recovered from a dislocated shoulder to win his 76th cap.
But Gatland's list of absentees comprises Halfpenny, Jenkins, Jones, George North, Tom Shanklin, Andrew Bishop and Richie Rees.
Wales team to play England: J Hook (Ospreys); M Stoddart (Scarlets), J Roberts (Cardiff Blues), J Davies (Scarlets), S Williams (Ospreys); S Jones (Scarlets), M Phillips (Ospreys); P James (Ospreys), M Rees (Scarlets, capt), C Mitchell (Ospreys), B Davies (Cardiff Blues), A-W Jones (Ospreys), D Lydiate (Newport Gwent Dragons), S Warburton (Cardiff Blues), A Powell (Wasps).
Replacements (tbc): R Hibbard (Ospreys), J Yapp (Cardiff Blues), R Jones (Ospreys), J Thomas (Ospreys), D Peel (Sale Sharks), R Priestland (Scarlets), L Byrne (Ospreys).