Peter Horne will start his first game for Glasgow Warriors since the play-off defeat to Leinster last May when he lines up against Ulster at Scotstoun on Friday night.
The centre has been out injured for the majority of the season but returned to action earlier this month as a replacement in the win over Benetton Treviso and also featured as a substitute in last weekend's win at Munster.
Horne will line up at inside centre, with Mark Bennett coming in at outside centre and Finn Russell moving to stand-off in place of Duncan Weir.
It is the same back three which started at Thomond Park last Saturday, with Peter Murchie at full-back and Tommy Seymour and Sean Maitland on either wing.
Chris Cusiter, who will once again captain the side at scrum-half, will form a new half-back pairing with 21-year-old Russell.
There are no changes to the pack from last weekend's win over Munster so Gordon Reid, Dougie Hall and Jon Welsh line up in the front row and Tim Swinson and Jonny Gray are in the engine room.
Josh Strauss, Chris Fusaro and Ryan Wilson continue in the back-row.
Warriors head coach Gregor Townsend said: "Last week was a precious win for the club but we have another huge game in prospect at Scotstoun tomorrow night.
"Ulster are coming to Glasgow high on confidence and ahead of us in the league - so it's a very important game for both clubs.
"What impressed me most last weekend was our players workrate and how we kept taking the game to Munster. We'll need to repeat that effort again tomorrow.
"Our goal is to build on the win in Limerick and ensure we keep the momentum going over the next few weeks."