In-form Queen's looking to make the grade for a place in play-offs
Back-to-back bonus point wins has placed Queen's University fourth in 2A and the students now have an opportunity to push on as they travel to meet struggling Blackrock College.
Coach Derek Suffern's squad is expected to be pretty much the same as the one that defeated UL Bohemians last week and need to get a result as both Bohs and Old Crescent are sitting on the same total of 35 points as the students.
Centre Rory Bell shone in last Saturday's game at the Dub, and scored two tries, and another big game from him and skipper David Whitten could bring them a win.
In 2B, Belfast Harlequins must beat visitors Wanderers if they are to escape ninth spot, though the Deramore outfit will have taken some solace from the two points they collected from their narrow defeat at Greystones.
Dungannon, who are just two points ahead of Quins, host mid-table Galway Corinthians.
Third-placed Rainey Old Boys' home defeat to Sligo has certainly focused minds as their injury hit squad now visit Skerries.
In 2C, the North West derby between Omagh and City of Derry is hard to ignore as both come into the clash at Thomas Mellon Playing Fields from different places in the table. Bangor, in sixth, host seventh-placed Tullamore.
2A: Blackrock College v Queen's University
2B: Belfast Harlequins v Wanderers, Dungannon v Corinthians, Skerries v Rainey
2C: Bangor v Tullamore, Omagh v City of Derry