Australia outside centre Tevita Kuridrani will miss the clash with England at Twickenham due to an ankle injury.
The 23-year-old suffered the injury during the 26-23 defeat against Ireland in Dublin and his absence will be a blow for Australia, as the Fiji-born centre has scored three tries in his last six games.
Kuridrani's absence means that Wallabies coach Michael Cheika could move Adam Ashley-Cooper from the wing to plug the gap or could recall Kurtley Beale to his starting line-up.
Australia have only won one of their three games this autumn, a 33-28 victory over Wales. They were defeated 29-26 by France before losing to Ireland last weekend.