Richard Wigglesworth will start Leicester's Challenge Cup semi-final against Ulster at scrum-half ahead of Ben Youngs.
Veteran half-back Wigglesworth replaces England's first choice in the position to partner George Ford in the European showdown at Mattioli Woods Welford Road tonight.
Head coach Steve Borthwick said: "We have made a few changes as competition for places in this squad intensifies."
Ulster are packed with Ireland internationals, including full-back Jacob Stockdale and lock Iain Henderson, and reached the last-four after toppling Northampton 35-27.
"They are an excellent team. They have challenged at the top of the PRO14 for a while and were in the Champions Cup, which shows their calibre," Borthwick said. "We are excited by the challenge. This is a different competition and Ulster are the favourites to win it - probably rightly so.
"They have a history this season of winning knockout games in Britain."
The rivals - both former European Cup winners - are seeking a first appearance in the Challenge Cup final, where either Bath or Montpellier lie in wait. The second semi-final takes place at the Recreation Ground tomorrow night.
√ England No.8 Poppy Cleall has been voted 2021 Women's Six Nations Player of the Championship.
Cleall was named on a shortlist drawn up by a panel of experts alongside Red Roses team-mate and flanker Zoe Aldcroft and France wing Caroline Boujard.
The 28-year-old won 62 per cent of the public vote to follow in the footsteps of Emily Scarratt, the only previous winner of the award, and it comes after England were crowned after toppling France last weekend.
"It's already a huge moment to win back-to-back titles, but to win this award is thanks to all the hard work of those around me, from my coaches, team-mates and my family," Cleall said.