Warren Gatland admits the British and Irish Lions will face up to 10 weeks in their bubble environment if they are forced to quarantine on their return from South Africa.
The Lions are seeking elite sport exemption to avoid having to spend 11 nights in a government-approved hotel on arrival at Heathrow - the requirement for anyone travelling from a country placed on the red list.
Eleven England cricketers including Jos Buttler and Jason Roy are currently quarantining at hotels following their return from the Indian Premier League, which has been suspended because of the escalating coronavirus crisis in India.
Discussions between the Lions and the government are ongoing with the tourists hoping dispensation will be granted on the grounds they will be operating in a bubble with a regular testing programme in place.
But as it stands they must quarantine and with players meeting up for the first time for a training camp in Jersey in mid-June and returning from South Africa on August 9, Gatland knows his squad are facing an extended period away from home.
"The big challenge for us is being in the bubble in South Africa and potentially having to quarantine when we come back," the Lions head coach said.
"If you add in the two-week camp before we go it could be up to 10 weeks away and in a bubble.
"The rugby side takes care of itself so it's important we get the other stuff right and think about the players' wellbeing and mental health.
"The rugby's going to be the easy part. We need to get the other stuff right and then we've got a chance of performing on the field."
Players being required to quarantine for 10 full days on their return could create further conflict between the Lions and Gallagher Premiership clubs, who will face additional time without their stars.
The top flight only last week agreed to release players for the Jersey camp and warm-up Test against Japan at Murrayfield on June 26 and will baulk at the prospect of another 10 days being added to the extended mandatory rest period for England's Lions.
The tourists hope to publish their revised schedule for South Africa next week with the eight fixtures culminating in a three-Test series against the Springboks now taking place in Johannesburg and Cape Town only.