Omagh still aim for top four but Bangor's backs are to the wall
Though Omagh are not facing any relegation issues in 2C, they do have an outside chance of elbowing their way into the top four and a place in the play-offs.
The fifth-placed Accies host Ballina, who have already bagged the league title, and the Tyrone side must win and hope that Midleton do a job on Bruff to allow Omagh to finish up fourth.
Prior to the game, an Omagh Select team will play a Fire and Rescue Service side in memory of former Accies player Kenny McEwan (ko, 11.30).
Bangor's slump could still see them end up bottom and automatically relegated.
They must win, plus other results go their way, in order just to escape ninth and then play off to stay in senior rugby. Bangor host Malahide who could still lose third spot.
In 2B, Belfast Harlequins, in sixth, need to beat Galway Corinthians at Deramore to ensure their safety and potentially put the Connacht side in the play-offs in order to stay up.
Quins could also do Dungannon a favour as the eighth-placed Tyrone men are at Skerries who are in seventh and just one point ahead of Corinthians.
Rainey Old Boys, who have ensured third spot and a play-off at Greystones, host the league's runaway winners Barnhall.
In 2A, Queen's University are at Old Crescent and look certain to be meeting Buccaneers in the play-offs.
2A: Cresc v QUB. 2B: Rainey v Barnhall, Quins v Corinthians, Skerries v Gannon. 2C: Omagh v Ballina, Bangor v Malahide, Tullamore v Derry