The stakes are rising with seven games to go and this three-match segment could see significant movement towards resolving certain issues across the divisions.
The Ulster derby between Rainey Old Boys and Queen's University in Division 2A stands out, with just one point separating John Andrews' second-placed squad from the visiting students, who are fourth.
Throw in the fact that Queen's dramatically prevailed when the sides clashed in November at The Dub and that it's another occasion when the McMaster clan - Rainey assistant coach Terry and son Richie, who plays for Queen's - are wearing different colours and it should be quite tasty.
Former Ulster prop Tommy O'Hagan is back in a Rainey squad boosted by beating leaders Barnhall last time out.
Also in 2A, Ballymena, who are down in eighth, host third-placed Old Crescent.
In 2B, Belfast Harlequins, in eighth, are at bottom side Ballina while Dungannon, who are ninth, travel to Galwegians.
It's tight towards the bottom end of 2C with just one point separating City of Derry, in ninth, from seventh-placed Bangor. Both sides do battle this weekend in the north west in what will be a tense Ulster derby.
Fourth-placed Omagh host sixth-placed Skerries.
Division 2A: Ballymena v Old Crescent, Rainey Old Boys v Queen's University
Division 2B: Ballina v Belfast Harlequins, Galwegians v Dungannon
Division 2C: City of Derry v Bangor, Omagh v Skerries