Aviva Premiership club Sale Sharks have confirmed the departure of 21 players and four backroom personnel.
The list includes 2003 England World Cup winner Ben Cohen, number eight Sisa Koyamaibole, prop Jack Forster and back-row forward Kristian Ormsby.
Other departures, including fly-half Charlie Hodgson's move to Saracens, Chris Bell joining Wasps and Carl Fearns joining Bath, had previously been announced by their new clubs.
Off-the-field exits, meanwhile, include backs coach Byron Hayward and conditioner Peter Finch.
Sale, who finished third-bottom in the Premiership, have already made 12 new signings for next term, including Munster pair Tony Buckley and Sam Tuitupou.
"Such a wholesale change of players and coaching staff is necessary considering the performances of the club in the last two seasons," said Steve Diamond, Sale's executive director of sport.
"With a couple of exceptions, the club declined to make offers to the departing players and staff."
Sale chief executive Mick Hogan added: "There are still a number of signings and re-signings to be announced in the next fortnight.
"By the start of June, all players and coaches will be in place to start pre-season conditioning."