Campbell College enter the competition with a formidable team which includes a number of representative players, and should record a comfortable victory over a Regent team that is consolidating after reaching last season's quarter-final.
Regent played well but needed a try 12 minutes from time to narrowly overcome a young Limavady Grammar side 22-17 in the third round.
Coach Eric Sinnamon said: “This a local derby and one benefit is that we are at home. But, to be realistic, we have a very tough encounter. It was not the best draw for us but we will still relish the challenge.”
Campbell have the talent and plenty of depth as they have 20 competitive teams. Rob Haldane, Glen Bailie, Jan Francois Bester, Mark Best, Josh Cooke and Seb McBrien have all turned out for Ulster Under 18, while Christopher Best and Charles Gallagher have been on the Under 19s. If that is not enough Christopher Farrell and Rory Scholes, as well as their captain John Creighton, have played for Ireland.
At the start of the year they lost to Methody and Ballymena and drew with Inst but were far from full strength. Recently they proved too strong for Bangor 33-0, and Coleraine 40-0.
They are expertly coached by former Irish international Brian Robinson and Malone's versatile player Gareth Fry.