Edinburgh head coach Alan Solomons admits his side will be up against it as they take on Scarlets at Murrayfield without their Scotland internationals.
The Gunners have waved goodbye to front-rowers Al Dickinson, Ross Ford, WP Nel, Rory Sutherland and Stuart McInally as well as flanker John Hardie and scrum-half Sam Hidalgo-Clyne after they were all named in Vern Cotter's squad to face Italy in Rome on Saturday.
And with seven others out injured, Solomons confessed his side will have to be at their best to beat the Welshmen in Sunday's Guinness Pro12 clash.
The South African has made two changes to the team who lost to Ospreys last weekend, recalling wing Damien Hoyland and teenage full-back Blair Kinghorn.
Solomons said: "With international call-ups and injury this will yet again be a test of the strength in depth of our squad. Our players are looking forward to meeting the challenge this presents."