Billy Twelvetrees has demanded England re-establish their RBS 6 Nations title credentials when they face Scotland at Murrayfield on Saturday.
Stuart Lancaster's team have dropped to third favourites to win the 2014 Championship after slipping to an agonising opening-day defeat to France in Paris.
The Calcutta Cup must be retained if England are to have any chance of remaining relevant in the hunt to relieve Wales of their crown and Twelvetrees insists the outcome will be decided by brains as much as brawn.
"We still have massive belief we can win the title," said Twelvetrees.
"We're bitterly disappointed to lose our first game, but we've got four games in front of us that we want to win.
"It starts this weekend against Scotland, who will be hugely frustrated by their loss in Ireland on Sunday.
"They will be hugely motivated by a Calcutta Cup game against England at Murrayfield.
"It's a mouth-watering clash and we're hugely looking forward to it. It's going to be hugely physical and the team that is smarter will win.
"We are fully aware of what they are going to bring to the game. We've looked at how we can nullify that and assert ourselves in the game as well."
Twelvetrees won the first of his nine caps in last season's 38-18 defeat of Scotland at Twickenham, but the 25-year-old expects a different encounter to unfold at Murrayfield.
"I've got fond memories of last year against Scotland when I made my Test debut," he said.
"I will try to think of those memories because it was an enjoyable day for me, but they're a different team than they were last year and it will be a different encounter away from home.
"They'll be hugely physical at the breakdown, trying to slow down our ball and make it a physical game."
* Lock Jim Hamilton insists Scotland will have no problem bouncing back from defeat in Dublin – because they have done it all before.
The Dark Blues were dismal in the Irish capital as they lost 28-6 to Ireland in their opening RBS 6 Nations defeat.
He said: "It was the same old story in Dublin, but now we've got to get back on the wagon. It's a short turnaround before the next game and both ourselves and England will be desperate to win.
"There's no two ways about it, it'll be a tough game. It's always great to play at Murrayfield in the Calcutta Cup match and what positives we can take out of that game we'll try and do so.
"England lost their opening game to France, but the circumstances were different.
"England were extremely unlucky not to win in Paris, whereas we were well beaten by Ireland.
"England are a formidable team, we saw that in the autumn and barring the result in Paris they're one of the form teams in the Six Nations.
"It's a cruel sport and with Scotland over the last few years it has been tough. We're used to having disappointments but then bouncing back. We're well capable of running out a huge performance on Saturday."