The Guinness Six Nations game between Wales and Scotland at the Principality Stadium in Cardiff has been postponed as fears over the coronavirus grow.
The move represents a clean sweep of all top level sport being cancelled across Europe.
A Welsh Rugby Union statement read: "The WRU has maintained an open dialogue with, and continued to seek advice and direction from, the National Assembly for Wales and other stakeholders, including the Six Nations, on this fast-moving issue.
"Whilst medical advice remains consistent, we have decided that it is in the best interests of supporters, players and staff to fall in line with recent measures taken across the UK and global sports industries.
"The WRU would like to thank all parties for their counsel on the subject and will make further announcements with respect to rescheduling the fixture in the coming days.
"Every effort has been made to stage this game and we appreciate that individuals will have been inconvenienced. Given the fluid and unprecedented nature of this issue, a postponement became the only viable option."
The news came shortly after the Scottish Rugby Union confirmed that all rugby in Scotland had been postponed.