Elliot Daly is set to make English bow after impressing Eddie Jones
England will revert back to a five-three split on the bench between forwards and backs after reinforcing their pack with an extra lock for Saturday's Six Nations meeting with Ireland.
Courtney Lawes has been left out after failing to make an impression in their the 40-9 victory over Italy in favour of Maro Itoje, who has kept his place on the strength of a second-half cameo on his debut.
Elliot Daly will make his debut after competing with Luther Burrell and Sam Hill to supply midfield cover for Owen Farrell and Jonathan Joseph against Ireland, winning out on the strength of his performances for Wasps this season.
The 23-year-old has been used predominantly at an outside centre. Jones believes he covers a range of positions, however.
"We ran Elliot Daly at 12 on Monday and he picks up things very quickly. I was impressed with him," Jones said.
Jones was less glowing in his assessment of Daly after Italy were routed when asked how close the Croydon-born threequarter was to displacing Joseph, who repaid his coach's faith with a hat-trick against in Rome.
"I've never said Elliot is a Test 13. I said he is a good player," Jones said.
ENGLAND SQUAD: D Cole (Leicester Tigers), J Clifford (Harlequins), J George (Saracens), D Hartley (Northampton Saints, capt), J Haskell (Wasps), P Hill (Northampton Saints), M Itoje (Saracens), G Kruis (Saracens), J Launchbury (Wasps), J Marler (Harlequins), C Robshaw (Harlequins), B Vunipola (Saracens), M Vunipola (Saracens), M Brown (Harlequins), D Care (Harlequins), E Daly (Wasps), O Farrell (Saracens), G Ford (Bath Rugby), A Goode (Saracens), J Joseph (Bath Rugby), J Nowell (Exeter Chiefs), A Watson (Bath Rugby), B Youngs (Leicester Tigers).