Ahead of opening their Six Nations campaign against Ireland at the Aviva Stadium on February 7, Scarlets scrum-half Aled Davies is the only uncapped player in Wales' 37-man squad for the Championship.
Cardiff's Tom James is back after a six-year absence from the scene while Bath's Rhys Priestland is also included after reversing his decision to retire from the Test stage.
Captain Sam Warburton and Liam Williams are both included despite playing no rugby since the autumn but influential figures Leigh Halfpenny, Scott Williams and Rhys Webb all miss out through injury.
Head coach Warren Gatland said: "We have got a number of players that are going to be one or two weeks away from being able to train, that's why the squad is a little bit larger than we would normally select.
"We feel there's a nice balance between rewarding players for what they've done for us in the past and picking a couple of players that we've been impressed with at their club."
Scotland head coach Vern Cotter has called uncapped props Zander Fagerson and Rory Sutherland into his 36-man selection.
Should Fagerson, who turned 20 yesterday, appear during the Championship he would be Scotland's youngest prop since 1948.
Exeter Chiefs tight-head Moray Low and Glasgow hooker Pat McArthur have been recalled for the first time since 2014.
Scarlets' in-form flanker Jon Barclay is another to come back into the fold.