Paul Marshall will win his 150th Ulster cap against Edinburgh at Murrayfield tonight but injuries have ruled out both Luke Marshall and Robbie Diack.
here is some better news, though, as Ian Humphreys is fit enough for the bench and will make his first appearance of the season should he feature.
Luke Marshall is kept out with a thumb injury meaning his burgeoning centre partnership with Stuart McCloskey is broken up and Sam Arnold will make his second senior start in the 13 jersey.
The rest of the backline sees Neil Doak select a dangerous back three with Craig Gilroy - fresh from signing a contract extension this week that will keep him at the Kingspan Stadium until 2018 - and Andrew Trimble on the wings and Louis Ludik in his familiar position of full-back.
Having missed the game against Treviso, Nick Williams is back in the line-up, his return to No.8 seeing Roger Wilson move back into the blindside flanker role with Sean Reidy retaining his place at openside and Willie Faloon on the bench.
Diack picked up a thigh injury and is not available.
The tight five, always a key component against an Alan Solomons side, will be comprised of Callum Black, captain Rob Herring, Wiehahn Herbst, Franco van der Merwe and Dan Tuohy.
The latter will be out to prove a point after being overlooked for World Cup duty when Leinster's Mike McCarthy was selected to replace Paul O'Connell.
Rory Scholes will provide cover for the back three with David Shanahan ready should Paul Marshall not last the full 80 minutes.
Lewis Stevenson, a try-scorer last time out, is not rewarded with a start and is joined on the bench by fellow forwards John Andrew, Andy Warwick and Bronson Ross.