Wales wait on fitness updates on Scott Williams and Hallam Amos
Wales could make further injury-enforced changes to their World Cup squad ahead of next Thursday's key Millennium Stadium appointment with Fiji.
Centre Scott Williams and wing Hallam Amos are the latest major concerns after a stunning 28-25 victory over World Cup hosts England at Twickenham was accompanied by fresh injury anxiety.
Williams injured his knee, while Amos suffered a shoulder problem, and full-back Liam Williams was concussed after England flanker Tom Wood's swinging leg made contact with his head.
Updates on all three players could arrive on Monday, but it is thought that Scott Williams and Amos are doubts for the tournament remainder.
Wales head coach Warren Gatland has already lost the likes of Leigh Halfpenny, Rhys Webb and Cory Allen from his plans, yet the 2011 World Cup semi-finalists remain firmly on course for the last-eight after collecting nine points from a possible 10 in beating England and Uruguay.
Wales assistant coach Shaun Edwards said: "Hallam Amos and Scott Williams are definitely the biggest concerns, long-term. They are the ones who are the biggest concerns.
"But I think the resilience shown by these players means that if we have another player or two out of the World Cup, it just means someone else will step up and perform like we did last night."
If worst fears are confirmed with Williams and Amos, it could mean calls for the likes of James Hook, Gareth Anscombe or Tom Prydie, but Wales have little time to lick their wounds, with Fiji next up.
"We would probably look first at the original (training) squad, but we are in a situation now where we might have to spread our wings even further," Edwards added.
"Everybody is in our thoughts because we have had an incredibly bad run of luck with injuries."
Wales scrum-half Gareth Davies, meanwhile, hailed the Twickenham effort, which was highlighted by his late try and 23 points from fly-half Dan Biggar.
"I think all our hard work over the summer is paying off now," Scarlets number nine Davies said.
"In the 60th minute I felt as if the tide was turning. As a squad, we felt that those last 20 minutes was what we had worked for all summer, and we came through.
"It is a short turnaround to Fiji now. It is going to be another massive game. They have lost two (games), so they are going to want to prove a point."