Marcell Coetzee is out of the World Cup with the Ulster star set to undergo ankle surgery.
The 28-year-old earned a call into South Africa's training panel in June as he hoped to seal a spot in his country's final 31-man squad for the tournament in Japan. He went on to play 37 minutes of the Rugby Championship campaign.
However, an injury sustained during last weekend's 24-18 victory over Argentina means Ulster Rugby Writers' Player of the Year is out for 12 weeks, ruling him out of the World Cup.
Coetzee looks certain to miss Ulster's first six PRO14 outings but, iIf Coetzee's recovery goes to plan, he should return ahead of the province's first European Champions Cup fixture in November.
Earlier this year, he had underlined his desire to forge his way back into the South Africa squad.
"I’m very passionate about playing for the Boks,” he said. “Once you’ve had a taste of playing in the green and gold, it’s like an addiction and you just want to experience more and more.
“The one thing I can say is that if I should ever get the call-up, I’d jump at the chance. I’m still so passionate about the Springbok jersey and so all I can do is ensure that I’m performing well enough to be ready if the opportunity comes around again.”